| Cast list |
| Jack Black | as | Eddie Riggs (voice) |
| Tim Curry | as | Doviculus (voice) |
| Jennifer Hale | as | Ophelia (voice) |
| Robin Atkin Downes | as | Fletus (voice) |
| Courtenay Taylor | as | Killer Nun / Dominatrix (voice) |
| Lita Ford | as | Rima (voice) |
| Josh Robert Thompson | as | Healer / Additional voices (voice) |
| Kath Soucie | as | Lita Halford (voice) |
| Brian Posehn | as | Hunter (voice) |
| Richard Steven Horvitz | as | Kabbage Boy Guitarist (voice) |
| Kyle Gass | as | Kage the Kannonier (voice) |
| Yuri Lowenthal | as | Gravedigger - Watt-R-Boy |
| Zach Hanks | as | Lars Halford (voice) |
| Alex Fernandez | as | Mangus (voice) |
| Lemmy | as | The killmaster (voice) |
| Tara Platt | as | Dominatrix |
| Matthew Wood | as | Firebaron (voice) |
| David Boat | as | Reaper #3 / Fire Baron #3 (voice) |
| Rob Halford | as | General Lionwhyte / The Baron (voice) |
| Matthew Mercer | as | Gravedigger / Multiple Voices (voice) |
| Stephen Stanton | as | Multiple Characters (voice) |
| Rebecca Corry | as | Rock girls (voice) |
| David Sobolov | as | Bouncer / Pit Boss / Treeback / Druid (voice) |
| John Hawkes | as | Multiple Voices (voice) |
| Taylor M. Dooley | as | Multiple Characters (voice) |
| Brooks McBeth | as | Multiple characters (voice) |
