| Cast list | | Rachel Weisz | as | Hypatia | | Max Minghella | as | Davus | | Oscar Isaac | as | Orestes | | Ashraf Barhom | as | Ammonius | | Michael Lonsdale | as | Theon | | Rupert Evans | as | Synesius | | Richard Durden | as | Olympius | | Sami Samir | as | Cyril | | Manuel Cauchi | as | Theophilus | | Homayoun Ershadi | as | Aspasius | | Oshri Cohen | as | Medorus | | Harry Borg | as | Prefect Evagrius | | Charles Thake | as | Hesiquius | | Yousef 'Joe' Sweid | as | Peter | | Andre Agius | as | Boy | | Paul Barnes | as | Dignitary 2 | | Christopher Dingli | as | Student 2 | | Clint Dyer | as | Hierax | | Wesley Ellul | as | Guard #1 | | Angele Galea | as | Charition | | George Harris | as | Heladius | | Jordan Kiziuk | as | Hypatia's Disciple | | Ray Mangion | as | Crier via Canopica | | Alan Meadows | as | Rabbi | | Samuel Montague | as | Theatre Crier | | Alan Paris | as | Bodyguard no. 1 | | Christopher Raikes | as | Hellenistic Man | | Amber Rose Revah | as | Sidonia | | Charles Sammut | as | Philosopher 1 | | Nikovich Sammut | as | Roman officer 1 | | Juan Serrano | as | Dead jew (extra actor) |
| | Crew list: | | Alejandro Amenábar (Director) | | Alejandro Amenábar (Writer) | | Mateo Gil (Writer) |
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