| Cast list |
| Jenifer Lewis | as | Jackie Washington |
| Tim Curry | as | Edward Whatsett St. John |
| T.V. Blake | as | Antandra Washington (Jackie's Daughter) |
| Tangie Ambrose | as | Shaniqua Summers Wells (Jackie's Daughter) |
| Whoopi Goldberg | as | Nurse Ethyl Washington Rue Owens (Jackie's Sister) |
| Robert Bailey Jr. | as | Wilson Wells (Jackie's Grandson) |
| Loren Freeman | as | Kim (Jackie's Costume Designer) |
| Tom Arnold | as | Marvin Pritz (Jackie's Former Manager) |
| Patti Austin | as | Herself (Gospel Singer at Peaches' Funeral |
| Loretta Devine | as | Snookie Tate (Jackie's Childhood Friend) |
| Julie Hagerty | as | Pammy Dunbar (Host) |
| David Hyde Pierce | as | Perry (The Deaf Rehearsal Pianist) |
| Kathy Najimy | as | Lola Molina (Jackie's Stalker) |
| Isabel Sanford | as | Miss Krumes (Jackie's Play Mama) |
| JoBeth Williams | as | Jo Face (Jackie's Vocal Coach) |
