| Cast list | | Harry Connick Jr. | as | Denny Slamon | | Paula Cale | as | Donna | | Angie Harmon | as | Lilly Tartikoff | | Bernadette Peters | as | Barbara | | Regina King | as | Ellie Jackson | | Tammy Blanchard | as | Nicole Wilson | | Amanda Bynes | as | Jamie | | Amy Madigan | as | Fran Visco | | Swoosie Kurtz | as | Elizabeth | | Bruce McKinnon | as | Dean Bradfield | | John Benjamin Hickey | as | Blake Rogers | | Jackson Hurst | as | Josh | | Natasha "Sasha" Angelety | as | Graduate School Student | | Tyler Case | as | Young Sam | | Cooper Cason | as | Sam | | Jennifer Coolidge | as | Tish | | Travis Davis | as | Andy Marks | | Shanna Forrestall | as | Runner # 2 | | Griff Furst | as | Charlie Wilson | | Evan Gamble | as | Peter Wilson | | Geraldine Glenn | as | Former patient | | Rhoda Griffis | as | Bindy Hawn | | James Hebert | as | The Groom | | Louis Herthum | as | Dr. Banks | | Connor Hill | as | Young Sam | | Jeremy Evan Kerr | as | Waiter | | Seth Kozak | as | Peter Hawn | | Cynthia LeBlanc | as | Track and Field spectator | | Elton LeBlanc | as | Limo Chauffeur | | Naima Imani Lett | as | Nurse Carol | | Austin Lux | as | Matt Slamon, age 9 | | Ben Lux | as | Matt Slamon age 7 | | Andrew Matthews | as | Darrin Bradfield | | Melissa Suzanne McBride | as | Sally (as Melissa McBride) | | Joe Nemmers | as | Ron Perelman | | Lance E. Nichols | as | Dr. Brown | | Natalie Nicole | as | Breast cancer Survivor | | William Ragsdale | as | Andy Marks | | Abby Rao | as | Joey Lyn | | Sam Richardson | as | Matt Slamon age 4 | | Rob Salvador | as | College Student | | Lonnie Schaffer | as | Cancer patient | | Billy Slaughter | as | Runner #1 | | Trudie Styler | as | Tina | | Kim Wall | as | Marci | | Sophia Watson | as | Joey Lyn Slamon - age 7 | | Dawna Williams | as | Cancer Survivor | | Michael Wozniak | as | Businessman |
| | Crew list: | | Dan Ireland (Director) | | Vivienne Radkoff (Writer) | | Robert Bazell (Writer) |
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