| Cast list |
| Roberto Benigni | as | Roberto (segment "Strange to Meet You") |
| Steven Wright | as | Steven (segment "Strange to Meet You") |
| Joie Lee | as | Good Twin (segment "Twins") |
| Cinqué Lee | as | Evil Twin/Kitchen Guy (segment "Twins/Jack Shows Meg His Tesla Coil") |
| Steve Buscemi | as | Waiter (segment "Twins") |
| Iggy Pop | as | Iggy (segment "Somewhere in California") |
| Tom Waits | as | Tom (segment "Somewhere in California") |
| Joseph Rigano | as | Joe (segment "Those Things'll Kill Ya") (as Joe Rigano) |
| Vinny Vella | as | Vinny (segment "Those Things'll Kill Ya") |
| Vinny Vella Jr. | as | Vinny Jr. (segment "Those Things'll Kill Ya") |
| Renee French | as | Renée (segment "Renée") (as Renée French) |
| E.J. Rodriguez | as | Waiter (segment "Renée") |
| Alex Descas | as | Alex (segment "No Problem") |
| Isaach De Bankolé | as | Isaach (segment "No Problem") |
| Cate Blanchett | as | Cate/Shelly (segment "Cousins") |
