| Cast list |
| Maurice Benard | as | Sonny Corinthos / ... (553 episodes, 1993-2008) |
| Steve Burton | as | Jason Morgan (501 episodes, 1991-2008) |
| Rebecca Herbst | as | Elizabeth Webber / ... (463 episodes, 1997-2008) |
| Laura Wright | as | Carly Jacks / ... (434 episodes, 2005-2008) |
| Julie Berman | as | Lesley Lu 'Lulu' Spencer / ... (434 episodes, 2005-2008) |
| Kelly Monaco | as | Samantha 'Sam' McCall / ... (418 episodes, 2003-2008) |
| Ingo Rademacher | as | Jasper 'Jax' Jacks / ... (395 episodes, 1996-2008) |
| Bradford Anderson | as | Damien Spinelli / ... (370 episodes, 2006-2008) |
| Greg Vaughan | as | Lucky Spencer / ... (359 episodes, 2003-2008) |
| Ted King | as | Lorenzo Alcazar / ... (355 episodes, 2002-2007) |
| Tyler Christopher | as | Nikolas Cassadine / ... (349 episodes, 1996-2008) |
| Nancy Grahn | as | Alexis Davis / ... (347 episodes, 1996-2008) |
| Kimberly McCullough | as | Dr. Robin Scorpio / ... (324 episodes, 1985-2008) |
| Kirsten Storms | as | Maxie Jones / ... (305 episodes, 2005-2008) |
| Alicia Leigh Willis | as | Courtney Matthews Quartermaine Morgan Jacks / ... (299 episodes, 2001-2006) |
| Jason Thompson | as | Dr. Patrick Drake / ... (296 episodes, 2005-2008) |
| Megan Ward | as | Kate Howard (288 episodes, 2007-2008) |
| Rick Hearst | as | Ric Lansing / ... (263 episodes, 2002-2008) |
| Sebastian Roché | as | Jerry Jacks / ... (261 episodes, 2007-2008) |
| Lindze Letherman | as | Georgianna "Georgie" Jones Quartermaine / ... (254 episodes, 2002-2007) |
| Anthony Geary | as | Luke Spencer / ... (243 episodes, 1978-2008) |
| Brandon Barash | as | Johnny Zacchara (239 episodes, 2007-2008) |
| Sarah Brown | as | Claudia Zacchara / ... (224 episodes, 1996-2008) |
