| Cast list |
| Akio Ôtsuka | as | Thadeus (Japanese version) |
| Clayton Watson | as | Michael Karl Popper AKA The Kid (segment "Kid's Story") (voice) |
| Pamela Adlon | as | Jue (segment "Final Flight of the Osiris")/Manabu (segment "Beyond") (voice) |
| Hedy Burress | as | Cis (segment "Program")/Yoko (segment "Beyond") (voice) |
| Terrence 'T.C.' Carson | as | Clarence (voice) (as T.C. Carson) |
| Melinda Clarke | as | Alexa (segment "Matriculated") (voice) |
| Olivia d'Abo | as | Rox (segment "Matriculated") (voice) |
| Dane A. Davis | as | 01 Versatran Spokesman (segment "The Second Renaissance, Part II") (voice) |
| John DeMita | as | Teacher (segment "Kid's Story") (voice) |
| Debi Derryberry | as | Kid (segment "The Second Renaissance, Part II") (voice) |
| John Di Maggio | as | Crew Man (segment "Final Flight of the Osiris")/Kaiser (segment "Program") |
| Alex Fernandez | as | Tom (segment "World Record") (voice) |
| Jack Fletcher | as | Townsperson (segment "Beyond")/Sandro (segment "Matriculated") (voice) |
| Julia Fletcher | as | The Instructor (segments "The Second Renaissance, Parts I&II")/Narrator (segment "World Record")/Townsperson (segment "Beyond") (voice) |
| Bette Ford | as | Old Woman (segment "Final Flight of the Osiris") (voice) |
| Rick Gomez | as | Pilot (segment "Final Flight of the Osiris") (voice) |
| Tom Kenny | as | Operator (segment "Final Flight of the Osiris") (voice) |
| Phil LaMarr | as | Duo (segment "Program") (voice) |
| Tress MacNeille | as | Housewife/Kenny (segment "Beyond") (voice) |
| Matt McKenzie | as | Agent #1 (segment "World Record")/Agent (segments "Beyond" and "A Detective Story") (voice) |
| Carrie-Anne Moss | as | Trinity (segments "Kid's Story" and "A Detective Story") (voice) |
| Keanu Reeves | as | Neo (segment "Kid's Story") (voice) |
| Kevin Michael Richardson | as | Thadeus (segment "Final Flight of the Osiris")/Cop (segment "Kid's Story")/Agent #2 (segment "World Record") (voice) |
| Rodney Saulsberry | as | Chyron (segment "Matriculated") (voice) |
| Dwight Schultz | as | Townspeople, Policeman, Exterminators (segment "Beyond")/Nonaka (segment "Matriculated")/Additional voice (segments "The Second Renaissance, Part I&II") (voice) |
| Allison Smith | as | Reporter (segment "World Record") (voice) |
| Kath Soucie | as | Pudgy/Masa/Sara (segment "Beyond") (voice) |
| Tara Strong | as | Crew Woman (segment "Final Flight of the Osiris")/Nurse (segment "World Record")/Misha (segment "Beyond") (voice) |
| Jill Talley | as | Mother/Additional voice (segments "The Second Renaissance, Parts I&II")/Townsperson (segment "Beyond") (voice) |
| James Arnold Taylor | as | Additional voice (segments "The Second Renaissance, Parts I&II)/Miscellaneous (segment "Kid's Story")/Ash (segment "A Detective Story")/Raul (segment "Matriculated") (voice) |
| John Wesley | as | Dan's Dad (segment "World Record") (voice) |
| Victor Williams | as | Dan (segment "World Record") (voice) |
