| Cast list | | Jenna Fischer | as | Darlene | | John C. Reilly | as | Dewey Cox | | John Michael Higgins | as | Record Producer | | Angela Little | as | Beth Anne (as Angela Little Mackenzie) | | Kristen Wiig | as | Edith Cox | | Jack White | as | Elvis Presley (rumored) | | Skyler Gisondo | as | Dewey Jr. | | Craig Robinson | as | Bobby Shad | | Debra Ling | as | Asian Groupie | | David Pearl | as | Concert Patron | | Conner Rayburn | as | Young Dewey Cox | | Simon Helberg | as | Dreidel L'Chaim | | Brittany Madelynn Daniels | as | Groupie | | Matt Besser | as | Dave | | Patrick J. Adams | as | The Kid | | Hannah Leigh Dworkin | as | Little sister | | Wendy Worthington | as | Woman - Talent Show | | Scarlett Keegan | as | Fiddle Player | | John Ennis | as | The Big Bopper | | Jennifer Lee Keyes | as | TV show dancer | | Isabella Astor | as | Daughter of Dewey Cox | | Jay Bird | as | Rock Star | | Dawn Morrow | as | 50's Dancer | | Ron Fassler | as | Ed Sullivan | | Matt Price | as | Mr. Hammel | | Monique La Barr | as | Gina Lynn | | Terrence Beasor | as | Doctor | | Oscar Dillon | as | Heckler/Audience Guy | | London Freeman | as | Dewey's Daughter | | Christopher Hurt | as | Dewey Cox Four Drummer | | Rian Bishop | as | Concert Patron | | Jennifer Novick | as | Groupie | | Sean Elmore | as | Dewey's son | | John Maynard | as | Man At Talent Show | | Nicola Randolph | as | Hotel Groupie | | Amy Minderhout | as | Mary Sue | | Chip Hormess | as | Nate | | Lauren Kelly | as | Hotel Groupie | | Michael William Arnold | as | Dewey's kid | | Tyler Nilson | as | Bert | | Jack White | as | Elvis | | Lee Ryder | as | Press | | Keith Ewell | as | Heckler | | Tyler Farrell | as | 70's House Party Guest | | Taylor Hubert | as | Dewey Cox Four Keyboard Player | | Monica Ford | as | 1959 Hotel Groupie #2 | | Christian J. Philippone | as | Hotel Groupie | | Lurie Poston | as | Cox Grandson | | Christopher Ausburn | as | Grandson | | Patrick Faucette | as | Badmen Bass Player | | Lu Johnson | as | 70's CBS Studio Member | | Kevin Montgomery | as | Daniel Cox | | Nicolas Quartermoon Mandelstein | as | Party guy | | Shavonne Burleigh | as | Dancer | | Isabella Cascarano | as | Actress | | Taliah Sampson | as | Granddaughter | | Ryan Elmore | as | Dewey's son | | Jason Elmore | as | Dewey's son |
| | Crew list: | | Jake Kasdan (Director) | | Judd Apatow (Writer) | | Jake Kasdan (Writer) |
|
