| Cast list | | George Clooney | as | Jimmy 'Dodge' Connelly | | John Krasinski | as | Carter Rutherford | | Renée Zellweger | as | Lexi | | Stephen Root | as | Suds | | Wayne Duvall | as | Coach Frank Ferguson | | Keith Loneker | as | Big Gus | | Malcolm Goodwin | as | Bakes | | Matt Bushell | as | Curly | | Tim Griffin | as | Ralph | | Robert Baker | as | Stump | | Nick Paonessa | as | Zoom | | Jonathan Pryce | as | CC | | Ezra Buzzington | as | Referee | | Christy Johnson | as | Chicago Teamer | | Ron Clinton Smith | as | Bouncer | | Mark Teich | as | Joe | | Mert Hatfield | as | Mayor | | John Vance | as | Suicidal Man | | Jim Keisler | as | Duluth Bulldogs Trainer | | Pete Pastore | as | Loud Fan | | Jason Drago | as | Toledo Player #1 | | Bill Roberson | as | Mr. Dunn | | Susan Crosby | as | Infield Fan | | Craig S. Harper | as | Princeton Reporter | | Leslie Dawn Forsyth | as | Female Referee | | Steve Rosswick | as | Angry Man | | Hi Bedford-Roberson | as | Mrs. Dunn |
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