| Cast list |
| Yôji Matsuda | as | Ashitaka (voice) |
| Yuriko Ishida | as | San (voice) |
| Yûko Tanaka | as | Eboshi-gozen (voice) |
| Kaoru Kobayashi | as | Jiko-bô (voice) |
| Masahiko Nishimura | as | Kouroku (voice) |
| Tsunehiko Kamijô | as | Gonza (voice) |
| Sumi Shimamoto | as | Toki (voice) |
| Tetsu Watanabe | as | Yama-inu (voice) |
| Mitsuru Satô | as | Tatari-gami (voice) |
| Akira Nagoya | as | Usi-kai (voice) |
| Akihiro Miwa | as | Moro-no-kimi (voice) |
| Mitsuko Mori | as | Hii-sama (voice) |
| Hisaya Morishige | as | Okkoto-nusi (voice) |
| Pamela Adlon | as | Additional Voices (voice: English version) (as Pamela Segall) |
| Gillian Anderson | as | Moro (voice: English version) |
| Lewis Arquette | as | Additional Voices (voice: English version) |
| Corey Burton | as | Additional Voices (voice: English version) |
| Jennifer Cihi | as | Tatara's Women Song (voice: English version) |
| Billy Crudup | as | Ashitaka (voice: English version) |
| Claire Danes | as | San (voice: English version) |
| Keith David | as | Okkoto/Additional Voices (voice: English version) |
| John DeMita | as | Kohroku (voice: English version) |
| Debi Derryberry | as | Additional Voices (voice: English version) |
| John Di Maggio | as | Gonza/Additional Voices (voice: English version) |
| Minnie Driver | as | Lady Eboshi (voice: English version) |
| Alex Fernandez | as | Additional Voices (voice: English version) |
| Jack Fletcher | as | Additional Voices (voice: English version) |
| Julia Fletcher | as | Additional Voices (voice: English version) (as Julia DeMita) |
| Pat Fraley | as | Additional Voices (voice: English version) (as Patrick Fraley) |
| Takako Fuji | as | Woman in Iron Town |
| John Hostetter | as | Additional Voices (voice: English version) |
| Leslie Ishii | as | Tatara's Women Song (voice: English version) |
| Yoshimasa Kondo | as | Additional Voices (voice: English version) |
| John Rafter Lee | as | Additional Voices (voice: English version) |
| Sherry Lynn | as | Iron Town Woman/Emishi Villiage Girl (voice: English version) |
| Tress MacNeille | as | Iron Town Woman/Additional Voices (voice: English version) |
| Mary Elizabeth McGlynn | as | Tatara's Women Song (voice: English version) |
| Matt McKenzie | as | Additional Voices (voice: English version) |
| Michael McShane | as | Additional Voices (voice: English version) |
| Matt K. Miller | as | Additional Voices (voice: English version) |
| Marnie Mosiman | as | Additional Voices (voice: English version) |
| Adam Paul | as | Additional Voices (voice: English version) |
| Jada Pinkett Smith | as | Toki (voice: English version) |
| David Rasner | as | Additional Voices (voice: English version) |
| Dwight Schultz | as | Additional Voices (voice: English version) |
| Tara Strong | as | Kaya (voice: English version) |
| Billy Bob Thornton | as | Jigo (voice: English version) |
| K.T. Vogt | as | Complaining Wife (voice: English version) |