| Cast list | | Drew Barrymore | as | Chloe (voice) | | Piper Perabo | as | Rachel Ashe Lynn | | Andy Garcia | as | Delgado (voice) | | George Lopez | as | Papi (voice) | | Cheech Marin | as | Manuel (voice) | | Paul Rodriguez | as | Chico (voice) | | Plácido Domingo | as | Monte (voice) | | Edward James Olmos | as | Diablo (voice) | | Loretta Devine | as | Delta (voice) | | Jamie Lee Curtis | as | Aunt Viv | | Luis Guzmán | as | Chucho (voice) | | Eddie 'Piolin' Sotelo | as | Rafa (voice) | | Carlos Juvera | as | Tomás (voice) | | Alex Mendoza | as | Frightened Terrier / Gang Leader Bull Dog (voice) | | Lombardo Boyar | as | Praying Dog |
| | Crew list: | | Raja Gosnell (Director) | | Analisa LaBianco (Writer) | | Jeffrey Bushell (Writer) |
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