| Cast list |
| William Hurt | as | Jason Renshaw (segment "Battleground") |
| William H. Macy | as | Clyde Umney/Sam Landry/George Demmick (episode: "Umney's Last Case") |
| Eion Bailey | as | Lonnie Freeman (segment "Crouch End") |
| Ron Livingston | as | Howard Fornoy (segment "The End of the Whole Mess") |
| Claire Forlani | as | Doris Freeman (segment "Crouch End") |
| Jeremy Sisto | as | Willie Evans (segment "The Fifth Quarter") |
| Henry Thomas | as | Robert Fornoy (segment "The End of the Whole Mess") |
| Kim Delaney | as | Mary Rivingham (episode: "You know they got a hell of a band") |
| Steven Weber | as | Clark Rivingham |
| Jacqueline McKenzie | as | Linda Landry/Gloria Demmick (episode: "Umney's Last Case") |
| Samantha Mathis | as | Karen Evans (segment "The Fifth Quarter") |
| Tom Berenger | as | Richard Kinnell (segment "The Road Virus Heads North") |
| Marsha Mason | as | Aunt Trudy (segment "The Road Virus Heads North") |
| Bill Barretta | as | Savage Commando |
| Jude Beaumont | as | Angela (segment 'Autopsy Room Four') |
| Portia Bradley | as | Daughter (segment 'You Know They Got a Hell of a Band') |
| Mitchell Butel | as | Alan Freed (segment 'You Know They Got a Hell of a Band') |
| Richard Cawthorne | as | Hot Rod Driver (segment 'You Know They Got a Hell of a Band') |
| Michelle Cele | as | Mother (segment 'You Know They Got a Hell of a Band') |
| Jennifer Congram | as | Concierge |
| Tyler Coppin | as | Richard Fornoy |
| Louis Corbett | as | Danny Landry |
| Jarrod Dean | as | The Freak |
| André de Vanny | as | Skater Boy (segment 'You Know They Got a Hell of a Band') |
| Sharon Fenech | as | Once Pretty Woman |
| Paul Gleeson | as | Ed Brooks (segment 'Autopsy Room Four') |
| Sara Gleeson | as | Thelma (segment 'The Fifth Quarter') |
| Kym Gyngell | as | Literary agent |
| Linal Haft | as | Archibald |
| Don Halbert | as | Dunninger |
| Linc Hasler | as | Rusty (segment 'Autopsy Room Four') |
| Masam Holden | as | English Boy (voice) |
| Fletcher Humphrys | as | Duane Allman (segment 'You Know They Got a Hell of a Band') |
| Nicholas Kadi | as | Soldier |
| Christopher Kirby | as | Sarge (segment 'The Fifth Quarter') (as Chris Kirby) |
| Bert Labonte | as | Otis Redding |
| John Lawson | as | ER Doctor 'Autopsy Room Four' |
| Joshua Lawson | as | ER Doctor - Autopsy Room four |
| Eva Lazzaro | as | Evil Child |
| Kirsty Lee | as | Moderator |
| Brian Lipson | as | Mike the Orderly (segment 'Autopsy Room Four') |
| Robert Mammone | as | Jagger (segment 'The Fifth Quarter')/Dr. Peter Jennings (segment 'Autopsy Room Four') |
| Dino Marnika | as | Detective #1 (segment 'The Fifth Quarter') |
| Brad McMurray | as | Security Guard (segment 'Battleground') |
| William McNamara | as | Ricky Nelson (segment "You Know They Got a Hell of a Band") |
| Andy McPhee | as | Pot Bellied Man (segment 'You Know They Got a Hell of a Band') |
| Hamish Michael | as | Bobby Hastings (segment: The Road Virus Heads North) |
| Christine Moffat | as | Mrs. Clausen (segment 'The Fifth Quarter') |
| Christopher Morris | as | Barney (segment 'The Fifth Quarter') |
| Tory Mussett | as | Arlene 'Candy' Cain/Pool Girl (episode: "Umney's Last Case") (as Victoria Musset) |
| Antony Neate | as | Prison Guard #1 (segment 'The Fifth Quarter') (as Anthony Neate) |
| Peter O'Brien | as | Keenan (segment 'The Fifth Quarter') |
| Julian O'Donnell | as | Peoria Smith (segment: Umney's Last Case) |
| Daniel Pirrone-Cook | as | Mexican Driver |
| Damien Richardson | as | Ronnie Van Zandt (segment 'You Know They Got a Hell of a Band') |
| Tony Rickards | as | Roy Orbison (segment 'You Know They Got a Hell of a Band') |
| Joe Sagal | as | Elvis Presley (segment "You Know They Got a Hell of a Band") |
| Mia Sara | as | Beautiful Passenger |
| Greta Scacchi | as | Dr. Katie Arlen (segment "Autopsy Room Four") |
| Kristian Schmid | as | Buddy Holly (segment 'You Know They Got a Hell of a Band') |
| Kodi Smit-McPhee | as | Jackson Evans (segment 'The Fifth Quarter') |
| Bruce Spence | as | Hans Morris |
| Jacinta Stapleton | as | Sissy (segment 'You Know They Got a Hell of a Band') |
| Richard Thomas | as | Howard Cottrell (segment "Autopsy Room Four") |
| Sigrid Thornton | as | Mrs. Sternwood (episode: "Umney's Last Case") |
| Che Timmins | as | Jimi Hendrix (segment 'You Know They Got a Hell of a Band') |
| Anita Torrance | as | Pretty Wiccan |
| Romi Trower | as | Howie's Date |
| Martin Vaughan | as | Dr. Kazalian (segment 'Autopsy Room Four') |
| Erin Wright | as | Janis Joplin (segment 'You Know They Got One Hell of a Band') |
