| Cast list | | Ben Stiller | as | Eddie Cantrow | | Michelle Monaghan | as | Miranda | | Jerry Stiller | as | Doc | | Malin Akerman | as | Lila | | Carlos Mencia | as | Uncle Tito | | Rob Corddry | as | Mac | | Stephanie Courtney | as | Gayla | | Ali Hillis | as | Jodi | | Kathy Lamkin | as | Lila's Mom | | Nicol Paone | as | Hostess | | Dean Norris | as | Bride's Father | | Lauren Bowles | as | Tammy | | Betsy Rue | as | Mimi | | Amy Sloan | as | Deborah | | Brian Vowell | as | Truck Driver | | David Pearl | as | Boyfriend | | Lorna Scott | as | Tourist Mom | | Danny R. McBride | as | Martin | | E.E. Bell | as | Tourist Dad | | Alejandro Patino | as | Juan immigrant father | | Johnny Sneed | as | Cal | | Mishon Ratliff | as | Kid in batting cage | | Sandra Ramírez | as | Consuela | | Brad Newman | as | Groomsman | | Joel Bryant | as | Michael | | David Hodges | as | Wedding Party Guest | | Donn Andrew Simmons | as | Wedding Guest | | Natalie Carter | as | Girl at wedding | | Miranda May | as | Tourist Daughter | | Michael Kromka | as | Twin | | Roy Jenkins | as | Buzz | | Nicholas Kromka | as | Twin | | Scott Updegrave | as | Wedding Guest |
| | Crew list: | | Bobby Farrelly (Director) | | Peter Farrelly (Director) | | Kevin Barnett (Writer) | | Leslie Dixon (Writer) |
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