| Cast list |
| Spencer Klein | as | Arnold (voice) |
| Francesca Smith | as | Helga Geraldine Pataki / Deep Voice (voice) (as Francesca Marie Smith) |
| Jamil Walker Smith | as | Gerald Martin Johanssen / Rasta Guy (voice) (as Jamil Smith) |
| Dan Castellaneta | as | Grandpa 'Steely' Phil / Nick Vermicelli (voice) |
| Tress MacNeille | as | Grandma Gertie 'Pookie' / Mayor Dixie / Red (voice) |
| Paul Sorvino | as | Scheck (voice) |
| Jennifer Jason Leigh | as | Bridget (voice) |
| Christopher Lloyd | as | Coroner (voice) |
| Vincent Schiavelli | as | Mr. Bailey (voice) |
| Maurice LaMarche | as | Big Bob Pataki / Head of Security (voice) |
| Kath Soucie | as | Miriam Pataki / Reporter (voice) (as Kath E. Soucie) |
| Christopher Walberg | as | Stinky Peterson (voice) (as Christopher P. Walberg) |
| Sam Gifaldi | as | Sid (voice) |
| Justin Shenkarow | as | Harold Berman (voice) |
| Blake McIver Ewing | as | Eugene Horowitz (voice) (as Blake Ewing) |
