| Cast list | | Rupert Everett | as | Sherlock Holmes | | Nicholas Palliser | as | Dr. Dunwoody | | Neil Dudgeon | as | Lestrade | | Ian Hart | as | Dr. Watson | | Anne Carroll | as | Mrs. Hudson (as Anne Caroll) | | Tamsin Egerton | as | Miranda Helhoughton | | Perdita Weeks | as | Roberta Massingham | | Jennifer Moule | as | Georgina Massingham | | Eleanor David | as | Mary Pentney | | John Cunningham | as | Bates | | Michael Fassbender | as | Charles Allen | | Jonathan Hyde | as | George Pentney | | Gina Beck | as | Maid | | Helen McCrory | as | Mrs. Vandeleur | | Andrew Wisher | as | Constable (as Andy Wisher) |
| | Crew list: | | Simon Cellan Jones (Director) | | Allan Cubitt (Writer) | | Arthur Conan Doyle (Writer) |
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