| Cast list | | Meryl Streep | as | Karen Silkwood | | Kurt Russell | as | Drew Stephens | | Cher | as | Dolly Pelliker | | Craig T. Nelson | as | Winston | | Fred Ward | as | Morgan | | Diana Scarwid | as | Angela | | Ron Silver | as | Paul Stone | | Charles Hallahan | as | Earl Lapin | | Josef Sommer | as | Max Richter | | Sudie Bond | as | Thelma Rice | | Henderson Forsythe | as | Quincy Bissell | | E. Katherine Kerr | as | Gilda Schultz | | Bruce McGill | as | Mace Hurley | | David Strathairn | as | Wesley | | J.C. Quinn | as | Curtis Schultz |
| | Crew list: | | Mike Nichols (Director) | | Nora Ephron (Writer) | | Alice Arlen (Writer) |
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