| Cast list | | Gary Cooper | as | Wild Bill Hickok | | Jean Arthur | as | Calamity Jane | | James Ellison | as | William "Buffalo Bill" Cody | | Charles Bickford | as | John Lattimer | | Helen Burgess | as | Louisa Cody | | Porter Hall | as | Jack McCall | | Paul Harvey | as | Yellow Hand | | Victor Varconi | as | Painted Horse | | John Miljan | as | Gen. George A. Custer | | Frank McGlynn Sr. | as | Abraham Lincoln | | Granville Bates | as | Van Ellyn | | Frank Albertson | as | Young trooper | | Purnell Pratt | as | Capt. Wood | | Fred Kohler | as | Jake (teamster) (as Fred Kohler Sr.) | | Pat Moriarity | as | Sgt. McGinnis (as Pat Moriarty) |
| | Crew list: | | Cecil B. DeMille (Director) | | Courtney Ryley Cooper (Writer) | | Frank J. Wilstach (Writer) |
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