| Cast list |
| Robert Abrams | as | Capt. 'Sharky' Kirgo |
| Edward Asner | as | President Thomas D. Moss |
| Sharisse Baker-Bernard | as | Lt.Meryl McPherson (as Sharisse Baker) |
| Majel Barrett | as | NASA Chief Suzanne O'Dell |
| Carlos Bernard | as | Lt. Ronaldo Alvarez |
| Douglas Coler | as | Commdr. Hank Wyatt |
| Sibel Ergener | as | Lt. Natasha Bekov |
| Elaine Giftos | as | NASA Oversight Officer Gennifer Gianni |
| Christopher Gilman | as | Lt. Wolfgang Reinhardt |
| Koji Kataoka | as | Mister Jones |
| Crystal Kwon | as | Lt. Eiko Saito |
| Alain Lambert | as | Dr.Jacques Montand |
| Richard Lawson | as | Mission Flight Director Maynard Nixon |
| Greg Lewis | as | ISS Commander Vladimir Gagarin |
| Brandon Maggart | as | Dr. Henry J. Walker |
| Jack McGee | as | Dr. Zed Dangerworth |
| Richard McGonagle | as | Poppa Computer (voice) |
| Robin Riker | as | Lt. Fiona Boggs |
| Stanton Rutledge | as | Council of Eight - Mr. One |
| Jerome Seven | as | Council of Eight - Mr. Seven |
