| Cast list | | Frank Welker | as | Fred Jones /Scooby-Doo (voice) | | Casey Kasem | as | Norville 'Shaggy' Rogers (voice) | | Mindy Cohn | as | Velma Dinkley (voice) | | Grey DeLisle | as | Daphne / Natasha (voice) | | Christine Baranski | as | Amelia von Butch (voice) | | Ajay Naidu | as | Prince Omar (voice) | | Ron Perlman | as | Hotep / Ancient One #2 (voice) | | Jeremy Piven | as | Rock Rivers (voice) | | Wynton Marsalis | as | Campbell (voice) | | Oded Fehr | as | Amahl Ali Akbar (voice) | | Virginia Madsen | as | Cleopatra (voice) |
| | Crew list: | | Joe Sichta (Director) | | Joseph Barbera (Writer) | | George Doty IV (Writer) |
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