| Cast list |
| Naveen Andrews | as | Abby (segment "Planet Terror") |
| Melissa Arcaro | as | Venus Envy (segment "Death Proof") |
| Electra Avellan | as | Babysitter Twin #1 (segments "Death Proof"/"Planet Terror") |
| Elise Avellan | as | Babysitter Twin #2 (segments "Death Proof"/"Planet Terror") |
| Michael Bacall | as | Omar (segment "Death Proof") |
| Zoe Bell | as | Zoe (segment "Death Proof") |
| Michael Biehn | as | Sheriff Hague (segment "Planet Terror")/The Sheriff (segment "Thanksgiving") |
| Emily Booth | as | (segment "Don't") |
| Josh Brolin | as | Dr. William Block (segment "Planet Terror") |
| Nicolas Cage | as | Fu Manchu (segment "Werewolf Women of the SS") |
| Leroy Castanon | as | Sicko (segment "Planet Terror") |
| Cecilia Conti | as | Paramedic #1 (segment "Planet Terror") |
| Sybil Danning | as | Gretchen Krupp (segment "Werewolf Women of the SS") |
| Rosario Dawson | as | Abernathy (segment "Death Proof") |
| Omar Doom | as | Nate (segment "Death Proof") |
| Jason Douglas | as | Lewis (segment "Planet Terror") |
| Jamie L. Dunno | as | Lanna Frank Friend #2 (segment "Death Proof") |
| Eurlyne Epper | as | Lanna Frank Friend #1 (segment "Death Proof") |
| Jeff Fahey | as | J.T. (segment "Planet Terror") |
| Stacy Ferguson | as | Tammy (segment "Planet Terror") |
| Vanessa Ferlito | as | Arlene/"Butterfly" (segment "Death Proof") |
| Carlos Gallardo | as | Deputy Carlos (segment "Planet Terror") |
| Marcy Harriell | as | Marcy (segment "Death Proof") |
| Sammy Harte | as | Infected Girl (segment "Planet Terror") |
| Shannon Hazlett | as | Butterfly Foot Double (segment "Death Proof") |
| Jay Hernandez | as | Bobby (segment "Thanksgiving") |
| Olja Hrustic | as | Werewolf Woman (segment "Werewolf Women of the SS") |
| Doran Ingram | as | Patient (segment "Planet Terror") |
| Nicky Katt | as | Joe (segment "Planet Terror") |
| Greg Kelly | as | Rapist #2 (segment "Planet Terror") |
| Udo Kier | as | Franz Hess (segment "Werewolf Women of the SS") |
| Jordan Ladd | as | Shanna (segment "Death Proof")/Judy (segment "Thanksgiving") |
| Andrea Lee | as | Sicko |
| Jonathan Loughran | as | Jasper (segment "Death Proof") |
| Matthew Macfadyen | as | (segment "Don't) |
| Alicia Rachel Marek | as | Redhead Babe (segment "Machete") |
| Cheech Marin | as | Padre Benicio Del Toro (segment "Machete") |
| Andrew Martin | as | Nazi Boxer (segment "Werewolf Women of the SS") (as Test) |
| Rose McGowan | as | Cherry Darling (segment "Planet Terror")/Pam (segment "Death Proof") |
| John McLean | as | Sicko Coach (segment "Planet Terror") |
| Julio Oscar Mechoso | as | Romey (segment "Planet Terror") |
| Katie Melua | as | (segment "Don't") |
| Marta Mendoza | as | Punky Bruiser (segment "Death Proof") |
| Sheri Moon | as | Eva Krupp (segment "Werewolf Women of the SS") (as Sheri Moon Zombie) |
| Bill Moseley | as | Dr. Heinrich von Strasser (segment "Werewolf Women of the SS") |
| Tim Murphy | as | Tim the Bartender (segment "Death Proof") |
| Meriah Nelson | as | Werewolf Woman (segment "Werewolf Women of the SS") |
| Lorielle New | as | Werewolf Woman (segment "Werewolf Women of the SS") |
| Hung Nguyen | as | Dr. Crane (segment "Planet Terror") |
| Tommy Nix | as | Paramedic #2 (segment "Planet Terror") |
| James Parks | as | Edgar McGraw (segment "Death Proof") |
| Michael Parks | as | Earl McGraw (segments "Planet Terror"/"Death Proof") |
| Simon Pegg | as | Bearded Cannibal (segment "Don't") |
| Sydney Tamiia Poitier | as | Jungle Julia (segment "Death Proof") |
| Oleg Aleksandrovich Prudius | as | Nazi Boxer (segment "Werewolf Women of the SS") (as Vladimir Kozlov) |
| Skip Reissig | as | Skip (segment "Planet Terror") |
| Jeff Rendell | as | The Pilgrim (segment "Thanksgiving") |
| Johnny Reno | as | Sax Survivor (segment "Planet Terror") |
| Troy Robinson | as | Soldier #1 (segment "Planet Terror") |
| Freddy Rodríguez | as | El Wray (segment "Planet Terror") |
| Rebel Rodriguez | as | Tony Block (segment "Planet Terror") |
| Jerili Romeo | as | Ramona McGraw (segment "Planet Terror") |
| Christine Rose | as | Sicko (segment "Planet Terror") |
| Eli Roth | as | Dov (segment "Death Proof")/Tucker (segment "Thanksgiving") |
| Kurt Russell | as | Stuntman Mike (segment "Death Proof") |
| Felix Sabates | as | Dr. Felix (segment "Planet Terror") |
| Ava Santana | as | Sicko (segment "Planet Terror") (as Katie Knighten) |
| Tom Savini | as | Deputy Tolo (segment "Planet Terror") |
| Marley Shelton | as | Dr. Dakota Block (segments "Planet Terror"/"Death Proof") |
| Derek Southers | as | Soldier #2 (segment "Planet Terror") |
| Monica Staggs | as | Lanna Frank (segment "Death Proof") |
| Quentin Tarantino | as | The Rapist (segment "Planet Terror")/Warren (segment "Death Proof") |
| Tracie Thoms | as | Kim (segment "Death Proof") |
| Tom Towles | as | Lt. Boorman (segment "Werewolf Women of the SS") |
| Danny Trejo | as | Machete (segment "Machete") |
| Bruce Willis | as | Lt. Muldoon (segment "Planet Terror") |
| Stuart Wilson | as | Old Man (segment "Don't") |
| Mary Elizabeth Winstead | as | Lee (segment "Death Proof") |
