| Cast list |
| Glenn Close | as | Dr. Elaine Keener (segments "This is Dr. Keener" and "Fantasies about Rebecca") |
| Cameron Diaz | as | Carol Faber (segment "Love Waits For Kathy") |
| Calista Flockhart | as | Christine Taylor (segments "Goodnight Lilly, Goodnight Christine" and "This is Dr. Keener") |
| Kathy Baker | as | Rose (segments "Someone For Rose" and "Fantasies about Rebecca") |
| Amy Brenneman | as | Detective Kathy Faber (segment "Love Waits For Kathy") |
| Valeria Golino | as | Lilly (segment "Goodnight Lilly, Goodnight Christine") |
| Holly Hunter | as | Rebecca Waynon (segment "Fantasies About Rebecca") |
| Matt Craven | as | Walter (segments "Fantasies About Rebecca" and "Love Waits For Kathy") |
| Gregory Hines | as | Robert (segment "Fantasies About Rebecca") |
| Miguel Sandoval | as | Sam (segment "Fantasies About Rebecca") |
| Noah Fleiss | as | James aka Jay (segment "Someone For Rose") |
| Danny Woodburn | as | Albert (segments "Someone For Rose" and "Love Waits For Kathy") |
| Penelope Allen | as | Nancy (segment "Fantasies About Rebecca") (as Penny Allen) |
| Roma Maffia | as | Debbie (segment "Love Waits For Kathy") |
| Elpidia Carrillo | as | Carmen Alba (segment "Love Waits For Kathy" |
