| Cast list |
| Michelle Arthur | as | Moira, Female Prisoner #3 (voice) |
| Edward Asner | as | Morlock Healer (voice) |
| Dee Bradley Baker | as | Nightcrawler, Multiple Man, Mutant Prisoner, Morlock Guard, Cyborg Sentinel (voice) |
| Leigh Allyn Baker | as | Jean Grey (voice) |
| Eric Biessman | as | NYC Acolyte #1, Shadow Demon #1 |
| Steven Jay Blum | as | Wolverine (voice) (as Steven Blum) |
| Earl Boen | as | Colossus, Doctor (voice) |
| Rodger Bumpass | as | Sentinel Scientist (voice) |
| Cheryl Carter | as | Storm (voice) |
| Blaine Christine | as | Soldier #4 (voice) |
| Kathryn Cressida | as | Debra Owens, Computer Voice #1 (voice) |
| Grey DeLisle | as | Mystique, Child Bishop (voice) |
| John Di Maggio | as | Juggernaut, General Kincaid (voice) |
| Robin Atkin Downes | as | Cyclops, Pyro (voice) |
| Richard Doyle | as | Beast, Nuclear Tech #1, Acolyte #1 (voice) |
| Jeannie Elias | as | Illyana (voice) |
| Greg Ellis | as | Tecnician, Male Prisoner #2 (voice) |
| Nika Futterman | as | Computer Voice #2 (voice) (as Nika Frost) |
| Jay Gordon | as | Soldier #1 (voice) |
| Michael Gough | as | Soldier #3, Various (voice) |
| Dorian Harewood | as | Shadow King (voice) |
| Dan Hay | as | NYC Acolyte #2, Apocalypse (voice) |
| Bobby Holliday | as | Emma (voice) |
| Tony Jay | as | Magneto (voice) |
| Tom Kane | as | Chuck Simms, Additional Voices (voice) |
| Mark Klastorin | as | Blob, Mutant Prisoner, Acolyte #3 (voice) |
| Nancy Linari | as | Marrow (voice) |
| Peter Lurie | as | Avalanche, Sabretooth (voice) |
| Scott MacDonald | as | Gambit, Sentinel #1 (voice) |
| Erin Matthews | as | Rogue (voice) |
| Danica McKellar | as | Jubilee (voice) |
| Matt Prescott Morton | as | Soldier #2, Mutant #3, Brotherhood Mutant #2 (voice) |
| Masasa Moyo | as | Psylocke, Female Prisoner #4, Screaming Woman (voice) (as Masasa) |
| Matt Nolan | as | Havok, Brotherhood Mutant #3 (voice) |
| Lou Diamond Phillips | as | Forge (voice) |
| Zachary Quarles | as | Danger Room Computer, Shadow Demon #2, Male Morlock (voice) |
| Darren Scott | as | Iceman, HAARP Technician (voice) |
| Armin Shimerman | as | Toad, Male Prisoner #5 (voice) |
| André Sogliuzzo | as | Angel, Morlock Thief, Future Sentinel (voice) |
| Patrick Stewart | as | Professor Charles Xavier (voice) |
| Cree Summer | as | Magma (voice) |
| Rick Worthy | as | Acolyte #2, Man #2 (voice) |
| Kris Zimmerman | as | Female Civilian (voice) |
