| Cast list | | Christy Carlson Romano | as | Kim Possible (voice) | | Will Friedle | as | Ron Stoppable (voice) | | Nancy Cartwright | as | Rufus (voice) | | Tahj Mowry | as | Wade (voice) | | Mayim Bialik | as | Justine Flanner (voice) | | Dan Castellaneta | as | Drakken's Goons (voice) | | John Di Maggio | as | Dr. Drakken (voice) | | Brian George | as | Professor Ramesh (voice) | | Kerri Kenney | as | The Bebes (voice) | | Melissa McCarthy | as | DNAmy (voice) | | Breckin Meyer | as | Josh Mankey (voice) | | Raven-Symoné | as | Monique (voice) | | Roz Ryan | as | Wade's Mom (voice) | | Kirsten Storms | as | Bonnie Rockwaller (voice) | | Tara Strong | as | Britina (voice) | | Nicole Sullivan | as | Shego (voice) | | Lauren Tom | as | Yoshiko (voice) | | Patrick Warburton | as | Mr. Barkin (voice) | | Gedde Watanabe | as | Professor Bob Chen (voice) | | Jo Anne Worley | as | Mrs. Rockwaller (voice) |
| | Crew list: | | Chris Bailey (Director) | | Steve Loter (Director) | | Mark McCorkle (Writer) | | Madellaine Paxson (Writer) |
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