| Cast list |
| David Duchovny | as | Jake |
| Nina Siemaszko | as | Trudy (segment "Just Like That") |
| Tchéky Karyo | as | Phillip (segment "Just Like That") |
| Matt LeBlanc | as | Kyle ("Just Like That") |
| Maryam d'Abo | as | Zoe (segment "Another Woman's Lipstick") |
| Christina Fulton | as | The Other Woman (segment "Another Woman's Lipstick") |
| Kevin Haley | as | (segment "Another Woman's Lipstick") |
| Annabelle Gurwitch | as | Annie (segment "Another Woman's Lipstick") |
| Richard Tyson | as | Bud (segment "Talk To Me Baby") |
| Kim Burnette | as | Regina (episode "Talk To Me Baby") |
| Lydie Denier | as | Elaine (episode "Talk To Me Baby") |
| Lynn Speier | as | Rita (episode "Talk To Me Baby") |
| Peter Spellos | as | Emcee (episode "Talk To Me Baby") |
| Sheryl Lee | as | Kate Lyons (segment "Jake's Story") |
| William Paul Burns | as | Howard (episode "Jake's Story") (as William Burns) |
