| Cast list |
| Eminem | as | Himself / Slim Shady / Britney Spears |
| Kon Artis | as | Himself (segment "The Real Slim Shady") |
| Randall Barnwell | as | S&M partner |
| Bizarre | as | Himself (segment "The Real Slim Shady") |
| Robert Culp | as | Narrator (segment "Guilty Conscience") |
| D12 | as | Themselves (segment "The Real Slim Shady" |
| Dido | as | Stan's Girlfriend (segment "Stan") |
| Dr. Dre | as | Himself (segments "My Name Is" and "Guilty Conscience" |
| Fred Durst | as | Himself (segment "The Real Slim Shady") |
| Kathy Griffin | as | Nurse (segment "The Real Slim Shady") |
| Kuniva | as | Himself (segment "The Real Slim Shady") |
| Marilyn Manson | as | Himself (segment "The Way I Am") |
| Gheorghe Muresan | as | Ventriloquist (segment "My Name Is") |
| Proof | as | Himself (segments "The Real Slim Shady" and "The Way I Am") |
| Devon Sawa | as | Stan (segment "Stan") |
| Swift | as | Himself (segment "The Real Slim Shady") |
| Jane Yamamoto | as | Herself (segment "Stan") |
