| Cast list |
| Michael Galvin | as | Chris Warner / ... (59 episodes, 2003-2007) |
| Laura Hill | as | Toni Warner / ... (57 episodes, 2001-2007) |
| Fleur Saville | as | Libby Jeffries / ... (46 episodes, 1996-2007) |
| Toni Potter | as | Alice Piper (45 episodes, 2007) |
| Lucy Wigmore | as | Justine Jones (43 episodes, 2007) |
| Peter Mochrie | as | Callum McKay / ... (43 episodes, 2006-2007) |
| Tim Foley | as | Mark Weston / ... (42 episodes, 2004-2007) |
| Faye Smythe | as | Tania Jeffries / ... (42 episodes, 2003-2007) |
| Renato Bartolomei | as | Craig Valentine / ... (40 episodes, 2004-2007) |
| Glen Drake | as | Nurse Cameron Scott (1996-1997) / ... (40 episodes, 1996-1997) |
| Angela Marie Dotchin | as | Kirsty Knight (1992-1998) / ... (40 episodes, 1992-1998) |
| Alison James | as | Nurse Tiffany Pratt Warner Marinovich (1995-1998) / ... (40 episodes, 1995-1998) |
| Jennifer Ward-Lealand | as | Isobel Kearney (1996-1998) / ... (40 episodes, 1996-1998) |
| Ben Mitchell | as | TK Samuels (40 episodes, 2007) |
| Karl Burnett | as | Nick Harrison (1992-2005) / ... (39 episodes, 1992-2005) |
| Peter Elliott | as | Dr. David Kearney (1997-1999) (38 episodes, 1996-1999) |
| Tandi Wright | as | Nurse Caroline Buxton (1996-1999) / ... (38 episodes, 1996-1999) |
| Michaela Rooney | as | Dr. Emily Devine (1996-1997) / ... (38 episodes, 1996-1997) |
| Blair Strang | as | Paramedic Rangi Heremia (1995-2001) / ... (38 episodes, 1995-2001) |
| Irene Wood | as | Nurse Liz Stokes (1996-1997) / ... (37 episodes, 1996-1997) |
| Angela Bloomfield | as | Rachel McKenna (1992-1999, 2001-2003) / ... (37 episodes, 1996-1997) |
| Emily Robins | as | Claire Solomon (37 episodes, 2004-2007) |
| Stelios Yiakmis | as | Dr. Johnny Marinovich (1994-1999) / ... (36 episodes, 1994-1999) |
| Amanda Billing | as | Sarah Potts / ... (35 episodes, 2004-2007) |
| Mary Lose | as | Nurse Ana Fa'asolo / ... (35 episodes, 1995-1997) |
| Anna Jullienne | as | Maia Jeffries (35 episodes, 2007) |
| Kimberley Crossman | as | Sophie McKay (34 episodes, 2007) |
| Jaime Passier-Armstrong | as | Jay Copeland (34 episodes, 2004-2007) |
| John Leigh | as | Lionel Skeggins (1995-1998) / ... (34 episodes, 1995-1998) |
| Maggie Harper | as | Jenny Harrison (1992-1998, 2002) / ... (34 episodes, 1996-1997) |
| Luisa Burgess | as | Paramedic Rebecca Frost (1994-1997) / ... (34 episodes, 1994-1997) |
| Chris Dykzeul | as | James Thornton (1995-1998) / ... (34 episodes, 1995-1998) |
| Katherine McRae | as | Brenda Holloway (34 episodes, 2006-2007) |
| Lee Donoghue | as | Hunter McKay (33 episodes, 2007) |
| Tom Hern | as | Baxter Cormack / ... (33 episodes, 2005-2007) |
| David Press | as | Dr. Ian Seymour / ... (32 episodes, 1996-1997) |
| Andrew Laing | as | Nigel Bailey / ... (29 episodes, 1996-2003) |
| Stewart Turner | as | Dr. Gary Travis (28 episodes, 1996-1997) |
| Lynette Forday | as | Dr. Grace Kwan (1994-1998) / ... (26 episodes, 1994-1998) |
| Alison Quigan | as | Yvonne Jeffries / ... (26 episodes, 2003-2007) |
| Nicole Thomson | as | Scarlett Valentine (24 episodes, 2004-2007) |
